MOC31PE immunotoxin - targeting peritoneal metastasis from epithelial ovarian cancer

MOC31PE immunotoxin – targeting peritoneal metastasis from epithelial ovarian cancer

Peritoneal metastasis (PM) is an important feature of epithelial ovarian cancer (EOC) and is a frequent site of drug resistant disease recurrence, identifying PM-EOC an important clinical challenge. The MOC31PE immunotoxin targets and kills tumor cells expressing the epithelial cell adhesion molecule (EpCAM), which is highly expressed in EOC, and MOC31PE is being investigated for use in treatme...

Peritonectomy Procedures and HIPEC for Peritoneal Metastasis from Ovarian Cancer

Peritoneal carcinomatosis (PC) is the most impressive and frequent evidence of locoregional spread of epithelial ovarian cancer (EOC). For most of its natural history, PC remains confined to the peritoneal district, thus representing a target for various combinations of surgery and systemic or loco-regional chemotherapy. PC is observed both in primary settings, i.e. in patients first treated fo...

Targeting Signaling Pathways in Epithelial Ovarian Cancer

UNLABELLED Ovarian carcinoma (OC) is the most lethal gynecological malignancy. Response to platinum-based chemotherapy is poor in some patients and, thus, current research is focusing on new therapy options. The various histological types of OC are characterized by distinctive molecular genetic alterations that are relevant for ovarian tumorigenesis. The understanding of these molecular pathway...

The MOC31PE immunotoxin reduces cell migration and induces gene expression and cell death in ovarian cancer cells

BACKGROUND The standard treatment of ovarian cancer with chemotherapy often leads to drug resistance and relapse of the disease, and the need for development of novel therapy alternatives is obvious. The MOC31PE immunotoxin binds to the cell surface antigen EpCAM, which is expressed by the majority of epithelial cancers including ovarian carcinomas, and we studied the cytotoxic effects of MOC31...

Ovarian Metastasis in Endometriod Type Endometrial Cancer